A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a

In a pioneering study, we showed that a naturally occurring compound (anisomelic acid), as well as synthetic derivatives that we have developed based on this compound, effectively degrade the HPV E6 and E7 oncoproteins, i.e., the carcinogenic proteins in the virus that are known to play a key role in promoting the devel opment of HVP-positive cancers, says cell biology professor John Eriksson

(Evergreen shrub). Escalloniaceae. 1 Dec 2016 Folic acid is a great putative marker and a target molecule for cancer diagnosis Abbreviations: MSN, mesoporous silica nanoparticle; FA, folic acid; Met, Targeted delivery of a novel anticancer compound anisomelic a 20 Jun 2018 Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas. Scientific Reports (IF 3.998) Pub Cloxyquin preferentially binds into the fatty acid binding site 5 (FA5) of the BSA binding of anisomelic acid: Spectroscopy and molecular dynamic simulations. Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate. Top Interacting Genes.

CAM, cIAP2, HPV: 5 : 2013: Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a Anisomelic acid, is one of the major compounds in Anisomeles malabarica (L.) R. Br., is a cembrane type diterpenoid, which can be synthesized chemically. Anisomeles malabarica (Lamiaceae) is an aromatic, densely pubescent, perennial herb, 1.2-2 m in height.

A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The stereoselective total synthesis of (±)-anisomelic acid (34) has been achieved starting from aldehyde 7, the ozonolysis product of geranyl acetate.

Our recent studies have demonstrated that a plant-derived diterpenoid compound, anisomelic acid (AA), induces apoptosis in cervical cancer cells. In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica particles (Chitosan-NR-MSP).

Ovatodiolide & anisomelic acid, two diterpenoid lactones from Anisomeles malabarica R.br @inproceedings{Purushothaman1975OvatodiolideA, title={Ovatodiolide & anisomelic acid, two diterpenoid lactones from Anisomeles malabarica R.br}, author={K. K. Purushothaman and B. Bhima-Rao and K. Kalyani}, year={1975} } In a pioneering study, we showed that a naturally occurring compound (anisomelic acid), as well as synthetic derivatives that we have developed based on this compound, effectively degrade the HPV E6 and E7 oncoproteins, i.e., the carcinogenic proteins in the virus that are known to play a key role in promoting the devel opment of HVP-positive cancers, says cell biology professor John Eriksson 2019-05-23 Preethy C.P., et al., 2013, “Analysis of the cytotoxic potential of anisomelic acid isolated from Anisomeles malabarica,” Scientia pharmaceutica; 81(2): 559-566. [ Web Reference ] Singh I., et al., 2010, “Anticonvulsant potential of Anisomeles malabarica leaves against experimentally induced convulsions in rats,” International Journal of Green Pharmacy; 4(3): 199-205.

2019-12-30

Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Annual Congress on Medicinal Chemistry, Pharmacology and toxicology July 30 - 31 , 2018 Amsterdam , Netherlands. Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Fang Cheng, Maria Sippola-Thiele, Patrik Eklund and John E Eriksson. Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- and duration-dependent manner. Acridine Orange & Ethidium Bromide (AO & EB) and Hoechst 33258 staining Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells.The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- … Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles mal - abarica . Recently, we have studied the mode of action of AA-mediated apoptosis A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof.

Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.
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1974.

Recently, we have shown that AA possesses both anticancer and antiviral activity.
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Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Rajendran Senthilkumar1, Yury Brusentsev2, Preethy Paul1, Fang Cheng1, Maria Sippola-Thiele1, Patrik Eklund2 and John E Eriksson1 1Turku Centre of Biotechnology, Finland 2Abo Akademi University, Finland

2. Our recent studies have demonstrated that a plant-derived diterpenoid compound, anisomelic acid (AA), induces apoptosis in cervical cancer cells. In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica particles (Chitosan-NR-MSP). ANISOMELIC-ACID Plant -- -- Wealth of India. Activities (1) ACE-Inhibitor 20 ug (weak activity) BETULINIC-ACID Plant -- 100.0 -0.63 Pavannasasivam, G., & M.U.S.

Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect.

Anisomelic acid (AA) (Fig. S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica, 7 which we have previously shown to be cytotoxic to oral and cervical cancer cells. 8 Recently, we have shown that AA induces apoptosis and cause cell cycle arrest in SiHa cervical cancer cells by specifically down-regulating the viral oncoproteins, E6 and E6, 9,10 which are the Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a 2019-05-23 · The essential oil of the plant is useful in uterine affections (6). The plant yields anisomelic acid, ovatodiolide, 4,7-epoxyovatodiolide, apigenin, terniflorin B, prunin-6”-p-comarate, maslinic acid, hederagenin, and arjunolic acid (6,7). Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect Senthil Rajendran , Didem Sen Karaman, Preethy Paul , EM Björk, M Odén, John Eriksson , Jessica Rosenholm Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. This article is from Scientia Pharmaceutica, volume 81.AbstractAnisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica.

19 Feb 2018 acetoxy malabaric acid and anisomelol are isolated as macrocyclic diterpenes, while anisomelic acid, ovatodlolide are as diterpenoid lactones, 19 Dec 2013 Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic 8 Jul 2014 acid activates the PKR pathway and induces apoptosis through diterpenoid anisomelic acid causes depletion of E6 and E7 viral.